The research paper presents an analysis of the interrelation between the lateral organisation profiles’ indicators and self-regulation features. The existence of significant distinctions in the processes of self-regulation among respondents with different variants of lateral profiles of the interhemispheric asymmetry is proved, as well as the common features of these processes that are peculiar to the individuals having identical options of the lateral profiles are also specified. The combination of general psychological and differential psychological approaches made it possible to establish multilevel connections between the functional asymmetry peculiarities and behavioural and personality self-regulation characteristics being put into practice within the action system aimed at arranging temporal and living space of a person. It was revealed that there is a logic connection between the characteristics of the self-regulation processes and the profiles of lateral organisation, conditioned by the interaction of the interhemispheric asymmetry’s native traits within the motor activity organisation having the experience gained during a person’s lifetime. The lateral organisation profiles with a more complex interrelation between sensory and motor systems are connected with the formation of personality and activity characteristics of voluntary activity’s self-regulation, acquired within the processes of education, upbringing and other forms of socialization. The research results can be used in vocational guidance campaigns, and for academic activity optimization. They can also be applied while implementing principles of differential education, as well as at the classes of mastering the self-regulation system.