Introduction. The influence of blended learning on the process of profiling secondary general education is an urgent pedagogical task. In modern educational conditions, new pedagogical technologies are used for learning processes, which are used in modern educational technologies. The aim of the study is to theoretically substantiate, develop a structural and functional model for the profiling of general education in conditions of blended learning and introduce the model into the learning process. Materials and methods. The research is based on such methodological approaches as: activity approach, systemic, environmental, competence-based, personality-oriented. Methods used: theoretical analysis method, generalization method, synthesis method, methods of mathematical and statistical data processing. Research results. The article presents a new structural and functional model of general education profiling, which, as experimental work has shown, of high quality of education, as well as high quality of the profiling process. The expediency of implementing the proposed model from the point of view of the application of blended learning technologies within the framework of a specialized profiling secondary school is substantiated.